RESEARCH · ALON GORENSHTEIN, MD
Neurocritical care and consciousness
Alon Gorenshtein’s neurocritical care research examines the interpretation of bedside signs of recovery after acute brain injury. The work focuses on how repeated observations change the picture offered by a single examination.
Research question
How soon does bedside command-following return after acute brain injury, and how stable is its first appearance?
Methods and findings
The retrospective study used MIMIC-IV records from 13,900 patients with acute brain injury and repeated motor examinations. It analyzed recovery while accounting for competing events, measured repeated changes in command-following, and examined concurrent sedation. The principal findings were checked in the multicenter eICU database.
Among patients who recovered command-following, the first observation was transient in 22.2%, and 62.4% crossed the threshold repeatedly. The external cohort showed similar patterns. The findings support interpreting the timing and stability of examinations in context. Because this is observational research, associations with sedation do not establish a causal effect.
Authorship
First author, with Yosef Adiniaev, Mahmud Omar, Yiftach Barash, Eyal Klang, and Oved Daniel.
Publications and sources
- The Unsteady Return of Bedside Motor Command-Following After Acute Brain Injury
Alon Gorenshtein, Yosef Adiniaev, Mahmud Omar, Yiftach Barash, Eyal Klang, Oved Daniel. Neurocritical Care (2026).
DOI: 10.1007/s12028-026-02624-x
Research summary updated October 26, 2026.